Establishing Robust Tandem Stenosis with Advanced Safety Enhancements by Using 3D Printing to Revolutionise Stenosis Generation
Project Lead
Dr Yung-Chih (Ben) Chen, Monash University
Project Team
Dr Marziyeh Anari, Monash University; Dr Taylah Banham, Monash University; Dr Yi Hua, Monash University; Dr Alex Pokrassen, Monash University;
Solution
This project aims to address this challenge by developing and validating a biocompatible 3D-printed Tandem Stenosis (TS) model using ApoE-deficient mice. The TS model offers enhanced accessibility and safety while maintaining effectiveness in studying plaque instability, thereby providing researchers with a reliable tool to investigate diabetic atherosclerosis more comprehensively.
Impact
Establishing the 3D-printed TS model promises significant impact by bridging the gap in current research methodologies. It facilitates more accurate and reproducible studies of plaque instability in diabetic conditions, potentially leading to the discovery of novel therapeutic strategies. Moreover, the model's commercial potential, supported by its patentability and cost-effectiveness, could stimulate innovation and collaboration across academic and industry sectors. Ultimately, this initiative not only aims to advance scientific understanding but also to drive economic growth through intellectual property development and enhanced research capabilities in cardiovascular health.